Hypha Discovery: Experts in Metabolite Synthesis
Purification
Structure elucidation
Natural Products
Supporting pharmaceutical and agrochemical companies globally
Your trusted partner in pharmaceutical and agrochemical R&D
What we do
Hypha Discovery is a specialist CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and late-stage derivatives of drugs and agrochemicals in discovery and development.
We are experts in the scalable synthesis, purification and identification of drug metabolites and oxidised derivatives of lead compounds, and also possess a wealth of experience in the production, purification and structure elucidation of natural products.
We also use our purification expertise to isolate and identify manufacturing impurities and degradation products.
NMR Spectroscopy and Structure Elucidation
NMR Spectroscopy and Structure Elucidation
• Quantitative NMR
• Interpretation and documentation of spectra
Solutions for metabolite synthesis
Hypha Discovery offer a comprehensive suite of techniques for provision of even the most difficult-to-synthesise metabolite, comprising chemical synthesis, recombinant enzymes such as PolyCYPs, microbial biotransformation, mammalian liver fractions as well as the purification of metabolites from biological matrices. We are also experts in the structure elucidation of metabolites by NMR spectroscopy.
Chemical Synthesis
Late-stage chemical glucuronidation
Mammalian biotransformation
Panels of liver S9s / microsomes
Microbial biotransformation
Proven panels of bacteria and fungi
Purification & structure elucidation
COAs, acquisition / interpretation of NMR data
Recombinant enzymes
PolyCYPs, PolyUGTs, hrCYPs, AOX, FMOs
Metabolite screening kits
Hypha has developed kits for scientists to make metabolites in their own labs.
PolyCYPs®+ screening kits provide a quick and convenient way to access CYP-derived and other phase I metabolites. Kits comprise 18 PolyCYP isoforms together with human aldehyde oxidase (AOX1) and the main human hepatic flavin-containing monooxygenase (FMO3). Other human FMO isoforms are available separately at Hypha. Inclusion of multiple PolyCYPs isoforms broadens coverage of reactions. They have been proven to produce human and other mammalian CYP-derived metabolites including multi-step metabolites and metabolites of low turnover drugs.
Simple, Effective, Scalable
Produce CYP, AOX & FMO metabolites
Generate multiple hydroxylated and other oxidised derivatives of lead compounds in parallel
PolyUGTs® screening kits can be used to screen for, and scale-up production of, a variety of glucuronides of drugs, agrochemicals and other small molecules. The 11 enzymes in the screening kit have been tested for biocatalytic activity against a variety of drugs that undergo glucuronidation. This includes the glucuronidation of alkyl and phenolic hydroxyls to form O-glucuronides, carboxylic acids to form acyl-glucuronides, and N-glucuronidation of aromatic nitrogen-containing systems and some non-aromatic alkyl N-moieties.
Purified UGTs in an easy-to-use kit format
Produce a wide variety of glucuronides
UDPGA co-factor included
About Us
Delivering a first class service to our clients worldwide
Expertise
Hypha Discovery is your trusted global partner. We are go-to experts for metabolite solutions and have worked with many of the top pharma and agrochemical companies worldwide to deliver projects.
Flexibility
We will work with you to design a custom solution that meets your needs and which can be adapted in response to project milestones.
Service
We pride ourselves on our client focused approach. Our scientists will work with you to personally deliver your project.
Hypha Discovery News
We’re excited that our PolyUGTs screening and scale-up kits are now available! They’re a super easy way to make glucuronides for MetID and testing in your own labs.
We are delighted that Matthew Allen and Xianfu Li have joined Hypha’s team recently. Xianfu’s area of expertise is metabolite identification and bioanalysis, and Matt joins us as Hypha’s Chemistry Lab Manager.
Our Q4 2024 newsletter focusses on accessing glucuronides, Hypha’s new PolyUGTTM kit, as well as our latest blog articles and paper picks.
Blog
Check out our “Metabolite Tales” blog articles on interesting aspects around drug metabolism and medicinal chemistry.
Brochures
Access brochures on drug metabolite synthesis, Hypha’s one-stop metabolite shop, the PolyCYPs platform and PolarExplorer.
Stay up to date with the latest news from Hypha Discovery
Sign up for our quarterly newsletters and monthly "Metabolite Tales" blog
Ready to begin? Our scientists are available to talk through your requirements
Hypha Discovery is a UK-based CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and new derivatives of drugs and agrochemicals in discovery and development.