Paper Picks
Take a look at our favourite publications around biotransformation and metabolism of drugs in Hypha’s “Paper Picks”.
Hypha's Paper Picks
Discover the recommendations made by the IQ Consortium Metabolite Bioanalysis Working Group around best practice in metabolite bioanalysis during drug development.
Find out why more focus should be placed on major metabolites of locally acting drugs such as the unusual gut metabolites of izencitinib.
Concerned about missing or unexplained metabolites? Checkout our paper pick for October 2023 for helpful case studies and advice.
Unusual biotransformation reactions uncovered at Genentech are featured in our paper pick for September 2023.
Our paper pick for August 23 describes an unexpected, slow-forming, and long half-life major metabolite of iclepertin
Our paper pick for July 2023 is an interesting and rare example of a discrete diglucuronide of GDC-0810 formed by glucuronidation on two different functional groups to a major circulating metabolite in humans.
Some super interesting biotransformations of navoximod were published by Shuai Wang and colleagues at Genentech in our paper pick for April 23
Who knew that this active hydroxylated metabolite discovered during clinical trials would help unearth some previously unknown structure-activity relationships?
A cracking paper just out on the complex MIST-relevant metabolism of ganaxolone is our paper pick for March 2023.
MetID guided target design is the topic of our paper pick for February 2023, published by Li and colleagues at Merck.
Major O-demethylated human metabolites of ivermectin that reduce Anopheles survival were made by Hypha’s microbial biotransformation system, and are the focus feature of our Q3 2023 newsletter.
Metabolites of the FDA approved anti-fungal drug rezafungin were made by Hypha’s microbial biotransformation system.
Stay up to date with the latest news from Hypha Discovery
Sign up for our quarterly newsletters and monthly "Metabolite Tales" blog
Ready to begin? Our scientists are available to talk through your requirements
Hypha Discovery is a UK-based CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and new derivatives of drugs and agrochemicals in discovery and development.